| Eric McCormack | ... | Will Truman (187 episodes, 1998-2006) |
| Debra Messing | ... | Grace Adler (187 episodes, 1998-2006) |
| Megan Mullally | ... | Karen Walker (187 episodes, 1998-2006) |
| Sean Hayes | ... | Jack McFarland (187 episodes, 1998-2006) |
| Shelley Morrison | ... | Rosario Salazar (75 episodes, 1999-2006) |
| Harry Connick Jr. | ... | Leo Markus (24 episodes, 2002-2006) |
| Leigh Allyn Baker | ... | Ellen (19 episodes, 1998-2006) |
 | Tom Gallop | ... | Rob (16 episodes, 1998-2006) |
| Bobby Cannavale | ... | Vince D'Angelo (15 episodes, 2004-2006) |
| Tim Bagley | ... | Larry (14 episodes, 2000-2006) |
| Leslie Jordan | ... | Beverley Leslie (12 episodes, 2001-2006) |
| Jerry Levine | ... | Joe (11 episodes, 2000-2006) |
| Michael Angarano | ... | Elliot (11 episodes, 2001-2006) |
| Blythe Danner | ... | Marilyn Truman (11 episodes, 2001-2006) |
| Gary Grubbs | ... | Harlin Polk (10 episodes, 1998-1999) |
| Debbie Reynolds | ... | Bobbi Adler (10 episodes, 1999-2006) |
| Mathew Botuchis | ... | Dave (8 episodes, 2004-2006) |
| Marshall Manesh | ... | Mr. Zamir (7 episodes, 1999-2003) |
| Gregory Hines | ... | Ben Doucette (7 episodes, 1999-2000) |
| Woody Harrelson | ... | Nathan (7 episodes, 2001) |
| Alec Baldwin | ... | Malcolm (6 episodes, 2005) |
| Laura Kightlinger | ... | Nurse Sheila / ... (6 episodes, 2000-2006) |
| Eileen Brennan | ... | Zandra (6 episodes, 2001-2006) |
| John Cleese | ... | Lyle Finster (6 episodes, 2003-2004) |
| Minnie Driver | ... | Lorraine Finster (6 episodes, 2003-2004) |
| John Ducey | ... | Jamie (5 episodes, 2004-2006) |
| Jamie Kaler | ... | Gary (5 episodes, 2002-2006) |
| Amy Crofoot | ... | Receptionist / ... (5 episodes, 1999-2004) |
| Molly Shannon | ... | Val Bassett (5 episodes, 1999-2004) |
| JoMarie Payton | ... | Mrs. Freeman (5 episodes, 1999-2000) |
| Kari Lizer | ... | Connie (5 episodes, 2001-2004) |
| Charles C. Stevenson Jr. | ... | Smitty (5 episodes, 2002-2006) |
| Dave Foley | ... | Stuart Lamarack (5 episodes, 2004) |
| Steve Paymer | ... | Steve (4 episodes, 1998-2002) |
| Sydney Pollack | ... | George Truman (4 episodes, 2000-2006) |
| Neil Vipond | ... | Julius (4 episodes, 2000-2002) |
| Corey Parker | ... | Josh (4 episodes, 2000) |
| Lesley Ann Warren | ... | Tina (4 episodes, 2001-2006) |
| Jon Fleming | ... | Russell (4 episodes, 2002-2005) |
| Emily Rutherfurd | ... | Joanne (4 episodes, 2002-2005) |
| Dan Futterman | ... | Barry (4 episodes, 2003) |
| Taye Diggs | ... | James Hanson (4 episodes, 2006) |
| Jeff Goldblum | ... | Scott Woolley (3 episodes, 2005) |
| Edward Burns | ... | Nick (3 episodes, 2005) |
| Dennis Satterfield | ... | Cook / ... (3 episodes, 1999-2005) |
| Brian A. Setzer | ... | Benji (3 episodes, 2005-2006) |
| Ellen Idelson | ... | Usherette / ... (3 episodes, 1998-2001) |
| Jeremy Forte | ... | Angry Man / ... (3 episodes, 2000-2002) |
| Patrick Dempsey | ... | Matthew (3 episodes, 2000-2001) |
| Sam Pancake | ... | Jimmy / ... (3 episodes, 2001-2004) |
| Suzanne Pleshette | ... | Lois Whitley (3 episodes, 2002-2004) |
| Judith Ivey | ... | Eleanor Markus (3 episodes, 2002) |
| Rip Torn | ... | Lionel Banks (3 episodes, 2002) |
| Mark Harelik | ... | Tim (3 episodes, 2004) |
| Jennifer Lopez | ... | Herself (3 episodes, 2004) |
| Eric Stoltz | ... | Tom / ... (2 episodes, 2005) |
| Bridget Flanery | ... | Viv Cassidy (2 episodes, 2005) |
| Kyla Dang | ... | Casey Truman (2 episodes, 2005-2006) |
| Dmitri S. Boudrine | ... | Man / ... (2 episodes, 2003-2005) |
| Todd Eckert | ... | Jurgen Franzblau (2 episodes, 1998) |
| Alex Boling | ... | Judge / ... (2 episodes, 1999-2003) |
| Earl Schuman | ... | Driver / ... (2 episodes, 1999-2003) |
| Tom Verica | ... | Danny (2 episodes, 1999-2002) |
| John Slattery | ... | Sam Truman (2 episodes, 1999) |
| Jennie Fahn | ... | Mom #3 / ... (2 episodes, 2000-2006) |
| Kathleen Marie Archer | ... | Delivery Woman / ... (2 episodes, 2000-2002) |
| Richard Assad | ... | Male Cabbie / ... (2 episodes, 2000-2002) |
| Cher | ... | Herself (2 episodes, 2000-2002) |
| Louis Giovannetti | ... | Cop / ... (2 episodes, 2000-2002) |
| Jason Stuart | ... | Stuart (2 episodes, 2000-2002) |
| Doug Devine | ... | Ottoman Buyer / ... (2 episodes, 2000-2001) |
| Mary Pat Gleason | ... | Sally (2 episodes, 2000) |
| Landry Allbright | ... | Nancy (2 episodes, 2001-2002) |
| Sandra Bernhard | ... | Herself (2 episodes, 2001-2002) |
| Mitch Kaplan | ... | Mitchie (2 episodes, 2001-2002) |
| Andrew Rosenbach | ... | Barney's Employee / ... (2 episodes, 2001-2002) |
| Brent Sexton | ... | Prison Guard (2 episodes, 2001-2002) |
| Parker Posey | ... | Dorleen (2 episodes, 2001) |
| Branden Williams | ... | Scott (2 episodes, 2001) |
| Kevin Bacon | ... | Himself (2 episodes, 2002-2006) |
| Rachel Quaintance | ... | Roz (2 episodes, 2002-2005) |
| Ralph Litt | ... | Judge Holcomb / ... (2 episodes, 2002-2004) |
| Peggy Lane | ... | Female Cab Driver / ... (2 episodes, 2002-2003) |
| Matthew McCray | ... | Jasper (2 episodes, 2002-2003) |
| Wells Rosales | ... | Waiter #2 (2 episodes, 2002-2003) |
| Gene Wilder | ... | Mr. Stein (2 episodes, 2002-2003) |
| Katie Couric | ... | Herself (2 episodes, 2002) |
| Lorry Goldman | ... | Rabbi (2 episodes, 2002) |
| Mary Beth McDonough | ... | Mom (2 episodes, 2002) |
| Joseph Will | ... | Bill (2 episodes, 2002) |
| Steve Hasley | ... | Carlo / ... (2 episodes, 2003-2006) |
| Rosanna Arquette | ... | Julie (2 episodes, 2003) |
| Karen Bankhead | ... | Burnadean (2 episodes, 2003) |
| Christian S. Anderson | ... | Man (2 episodes, 2004) |
| Robert Costanzo | ... | Paul (2 episodes, 2004) |
| Tim Curry | ... | Marion Finster (2 episodes, 2004) |
| Lee Garlington | ... | Annette (2 episodes, 2004) |
| Josh Keaton | ... | Sal (2 episodes, 2004) |
| Marissa Matrone | ... | Aunt Angie (2 episodes, 2004) |
| Gina Morelli | ... | Grandma (2 episodes, 2004) |
| Jamie-Lynn Sigler | ... | Ro (2 episodes, 2004) |
| Jeri Slaughter | ... | Dancer (2 episodes, 2004) |
| Benjamin Sprunger | ... | Matt (2 episodes, 2004) |
| Reed Alexander | ... | Jordan Truman / ... (2 episodes, 2005-2006) |
| Matt Crabtree | ... | Stage Manager (2 episodes, 2005-2006) |
| Lily Tomlin | ... | Margot (2 episodes, 2005-2006) |
| Steven Weber | ... | Sam Truman (2 episodes, 2005-2006) |
| Matthew J. Williamson | ... | Gene / ... (2 episodes, 2005) |
| Brooke Baumer | ... | Alex / ... (2 episodes, 2006) |
| Skyler Caleb | ... | Yatzick (2 episodes, 2006) |
| Gigi Goff | ... | Little Girl (2 episodes, 2006) |
| Nick Nervies | ... | Boy (2 episodes, 2006) |
| Jason Pierce | ... | Cater Waiter / ... (2 episodes, 2006) |
|
| Jhoni Marchinko | .... | executive producer / co-executive producer / ... (118 episodes, 1998-2004) |
| Bruce Alden | .... | producer / associate producer / ... (106 episodes, 1998-2006) |
| David Kohan | .... | executive producer (105 episodes, 1998-2006) |
| Max Mutchnick | .... | executive producer (103 episodes, 1998-2006) |
| Tim Kaiser | .... | producer / supervising producer / ... (99 episodes, 1998-2006) |
| James Burrows | .... | executive producer (91 episodes, 1999-2006) |
| Adam Barr | .... | consulting producer / co-executive producer / ... (83 episodes, 1998-2006) |
| Peter Chakos | .... | producer / associate producer (81 episodes, 1999-2006) |
| Steve Sandoval | .... | associate producer / producer (79 episodes, 2000-2006) |
| Jeff Greenstein | .... | executive producer / co-executive producer / ... (78 episodes, 1998-2004) |
| Alex Herschlag | .... | co-executive producer / executive producer / ... (73 episodes, 1999-2005) |
| Tracy Poust | .... | supervising producer / producer / ... (69 episodes, 2000-2006) |
| Jon Kinnally | .... | supervising producer / producer / ... (67 episodes, 2000-2006) |
| Laura Kightlinger | .... | consulting producer (54 episodes, 2000-2006) |
| Kari Lizer | .... | co-executive producer / consulting producer (51 episodes, 2000-2004) |
| Donald Petersen | .... | associate producer / producer (47 episodes, 2004-2006) |
| Bill Wrubel | .... | producer / co-producer / ... (40 episodes, 2001-2005) |
| Gail Lerner | .... | co-executive producer / producer / ... (32 episodes, 2002-2006) |
| Gary Janetti | .... | executive producer / supervising producer / ... (30 episodes, 2002-2006) |
| Jamie Rhonheimer | .... | producer (23 episodes, 2005-2006) |
| Abraham Higginbotham | .... | producer (22 episodes, 2005-2006) |
| Sally Bradford | .... | supervising producer / producer (18 episodes, 2005-2006) |
| Janis Hirsch | .... | co-executive producer (17 episodes, 2005-2006) |
| Greg Malins | .... | executive producer / co-executive producer (17 episodes, 2005-2006) |
| Kirk J. Rudell | .... | co-executive producer (17 episodes, 2005-2006) |
| John Riggi | .... | co-executive producer (12 episodes, 2005-2006) |
| Cynthia Mort | .... | consulting producer (10 episodes, 2001-2002) |
| Richard Rosenstock | .... | consulting producer (9 episodes, 2000-2001) |
| Dava Savel | .... | consulting producer (7 episodes, 1998-1999) |
| William Lucas Walker | .... | supervising producer (7 episodes, 1998-1999) |
| Michael Patrick King | .... | consulting producer (4 episodes, 1998-1999) |
| Tom Leopold | .... | consulting producer (2 episodes, 1998) |
| Eve Ahlert | .... | co-producer (2 episodes, 1999) |
| Kate Angelo | .... | producer (2 episodes, 2005-2006) |
| Tom Park | .... | line producer / live producer (2 episodes, 2005-2006) |
|
| Gary Ganetti | .... | co-executive producer (unknown episodes, 2005) |
| Suzy Mamann-Greenberg | .... | producer (unknown episodes) |
| |
|
| Sean Tuell | .... | best boy grip (187 episodes, 1998-2006) |
| Gary Howard Baum | .... | camera operator (164 episodes, 1998-2005) |
| David Tolsky | .... | assistant camera (114 episodes, 1998-2003) |
| Glenn K. Shimada | .... | camera operator (113 episodes, 1998-2006) |
| John Greene | .... | gaffer (111 episodes, 1998-2006) |
| Travers Hill | .... | camera operator (108 episodes, 1998-2006) |
| Joe Blaisdell | .... | camera operator (99 episodes, 1999-2006) |
| Alfie Cunningham | .... | key grip (98 episodes, 1999-2006) |
| Joe Garcia | .... | best boy electric (77 episodes, 1998-2002) |
| Paul Jacobsen | .... | lighting console programmer / lighting console operator (45 episodes, 1998-2000) |
| Philip N. Berardi | .... | best boy electric (23 episodes, 2002-2004) |
| Dic Alexander | .... | key grip (19 episodes, 1998-1999) |
| Carlos Arguello | .... | camera operator (14 episodes, 1998-1999) |
| Lance Billitzer | .... | camera operator (10 episodes, 2005-2006) |
| David Chameides | .... | camera operator (2 episodes, 2005-2006) |
| Kim Killingsworth | .... | lighting consultant (2 episodes, 2005-2006) |
|
| Ron Ervin | .... | grip (unknown episodes, 2000-2006) |
| Michael Carmine | .... | director of photography: second unit (unknown episodes) |
| Jon L. Kunkel | .... | camera operator (unknown episodes) |
| Justin M. Lubin | .... | still photographer (unknown episodes) |
| Michael R. Marquette | .... | assistant camera (unknown episodes) |
| Matthew Santo | .... | assistant camera: New York (unknown episodes) |
| David Yellin | .... | lamp operator (unknown episodes) |
| |
|
| Peggy Lane | .... | stand-in (184 episodes, 1998-2006) |
| Russ Sherman | .... | technical coordinator / technical director (112 episodes, 1998-2006) |
| Sally Bradford | .... | script coordinator / production assistant / ... (88 episodes, 1998-2004) |
| Jennifer Goldsmith | .... | assistant accountant (86 episodes, 1998-2003) |
| Sandy Flowers | .... | craft service (86 episodes, 2000-2006) |
| Eugene Lew | .... | production accountant (79 episodes, 1998-2002) |
| Julie Fleischer | .... | script supervisor (73 episodes, 2000-2006) |
| Steve Clark | .... | production assistant (71 episodes, 1998-2002) |
| David Malkoff | .... | production assistant (66 episodes, 2000-2004) |
| Zack Slovinsky | .... | assistant to executive producer / assistant to executive producers (66 episodes, 2001-2006) |
| Becky Opp | .... | production secretary / assistant production coordinator / ... (64 episodes, 2003-2006) |
| Steve Sandoval | .... | production coordinator (60 episodes, 1998-2004) |
| Ronna Spencer | .... | production coordinator / assistant production coordinator (60 episodes, 1999-2002) |
| Susan Garon | .... | assistant to co-executive producer / assistant to executive producer / ... (57 episodes, 1999-2002) |
| Daniella Quinones | .... | production assistant / executive assistant: David Kohan/Max Mutchnick / ... (49 episodes, 2000-2003) |
| Shannon Dixon | .... | assistant production coordinator (48 episodes, 2002-2004) |
| Janet Kagen | .... | script supervisor (47 episodes, 1998-2001) |
| Danielle Evenson | .... | production assistant / assistant to executive producer / ... (45 episodes, 2001-2004) |
| Steve Gabriel | .... | script coordinator / assistant to writer (45 episodes, 2002-2006) |
| Matt Bellanger | .... | assistant production coordinator / production assistant (43 episodes, 2000-2002) |
| Larry Cogan | .... | production accountant (42 episodes, 2002-2006) |
| Heather Hicks | .... | executive assistant: David Kohan/Max Mutchnick / assistant to executive producer / ... (38 episodes, 2002-2006) |
| Jill Freeman | .... | assistant to executive producer (35 episodes, 1998-2000) |
| Michelle Bochner | .... | assistant to writers / script coordinator (34 episodes, 1998-2000) |
| Mike Trail | .... | production assistant (34 episodes, 1999-2001) |
| Jason Ervin | .... | production assistant / production secretary (33 episodes, 2001-2005) |
| Julienne La Fleur | .... | assistant production accountant / assistant accountant (30 episodes, 2003-2006) |
| Katie Palmer | .... | story editor / executive story editor (29 episodes, 1999-2001) |
| Donald Petersen | .... | production assistant (27 episodes, 1998-2001) |
| Eric L. Hurd | .... | production assistant (26 episodes, 1998-2000) |
| Kate Barnow | .... | assistant to executive producer / assistant to executive producers (25 episodes, 2002-2004) |
| Jon Kinnally | .... | story editor / executive story editor (24 episodes, 1999-2000) |
| Tracy Poust | .... | story editor / executive story editor (24 episodes, 1999-2000) |
| Stacey K. Pantazis | .... | executive assistant (24 episodes, 2001-2002) |
| Laura Cochrane | .... | production assistant / production secretary (24 episodes, 2002-2003) |
| Amanda Kowalsky | .... | assistant to co-executive producers / assistant to co-executive producer (23 episodes, 2002-2005) |
| Chris Steimel | .... | production assistant (23 episodes, 2002-2004) |
| Amy Hubbs | .... | script coordinator / assistant to writer / ... (23 episodes, 2005-2006) |
| Christopher Fife | .... | assistant to writer / script coordinator (22 episodes, 2001-2002) |
| Lisa Borgnes | .... | assistant to writer (21 episodes, 2000-2001) |
| Melissa Strauss | .... | assistant to executive producer / executive assistant: David Kohan/Max Mutchnick / ... (21 episodes, 2003-2006) |
| Maggie McGarry | .... | executive assistant to executive producer / assistant: David Kohan/Max Mutchnick (20 episodes, 2000-2001) |
| Tracy Gaydos | .... | assistant production coordinator / production secretary (19 episodes, 1998-1999) |
| Michael S. Peters | .... | assistant to writers / assistant to writer (18 episodes, 1998-1999) |
| Patrick Vettraino | .... | assistant to co-executive producer (18 episodes, 2000-2001) |
| Ben Acker | .... | production assistant (17 episodes, 1999-2000) |
| Alissa R. Chulack | .... | production assistant (17 episodes, 2000-2001) |
| Danny Schrader | .... | production assistant / head production assistant (17 episodes, 2004-2006) |
| Michael Lacey | .... | assistant production coordinator / production secretary (17 episodes, 2005-2006) |
| Amy Askins | .... | production assistant (16 episodes, 2002-2003) |
| Kim Abram | .... | production assistant (16 episodes, 2003-2006) |
| Liz Prives | .... | production secretary (16 episodes, 2005-2006) |
| Marc Firek | .... | assistant to executive producer / assistant to co-executive producer / ... (15 episodes, 1999-2000) |
| Tracey Diana | .... | assistant to co-executive producers / assistant to co-executive producer (15 episodes, 2002-2003) |
| Jessica Gordon | .... | assistant to executive producer / production assistant (14 episodes, 2005-2006) |
| Cam Sanders | .... | assistant to writers (13 episodes, 2002-2003) |
| Genessa Davis | .... | assistant to accountants (13 episodes, 2003) |
| Courtney Boches | .... | network publicity intern (13 episodes, 2005-2006) |
| Tim Hayward | .... | assistant to executive producer (13 episodes, 2005-2006) |
| Steve Schifini | .... | production assistant (13 episodes, 2005-2006) |
| Leah Cramer | .... | production assistant (12 episodes, 2005-2006) |
| Kate Peris | .... | production assistant (11 episodes, 1999-2000) |
| Josh Silberman | .... | assistant to executive producer (11 episodes, 2005-2006) |
| Carrie Friedman | .... | assistant to executive producer (9 episodes, 2000) |
| Jessica Sultan | .... | assistant to executive producers / assistant to executive producer (9 episodes, 2003-2004) |
| Rick Vettraino | .... | assistant to co-executive producer (7 episodes, 2000-2001) |
| Colin Ebeling | .... | assistant to executive producer / assistant to writer (6 episodes, 2004) |
| Barry Langer | .... | assistant to writers (4 episodes, 2004) |
| Ryan Goldstein | .... | production assistant (4 episodes, 2006) |
| Tyler M. Hall | .... | assistant to co-executive producer (3 episodes, 2001-2002) |
| Ashley Barnett | .... | production assistant (3 episodes, 2004) |
| Bill Narducci | .... | production assistant (2 episodes, 1999) |
| John B. Field | .... | technical director (2 episodes, 2005-2006) |
| Tad Scripter | .... | technical supervisor (2 episodes, 2005-2006) |
| Eve Weston | .... | assistant to writer (2 episodes, 2006) |
|
| Laura Kightlinger | .... | writing consultant (unknown episodes, 1999) |
| Jamie French | .... | publicist (unknown episodes, 2003) |
| Jamie Fiench | .... | publicist (unknown episodes, 2005) |
| Vanessa Rojas | .... | production assistant (unknown episodes, 2005) |
| Liz Alexanian | .... | assistant to producer (unknown episodes) |
| John Arbuckle | .... | marine technician (unknown episodes) |
| Kate Burrow | .... | assistant to executive producer (unknown episodes) |
| Peter Hansen | .... | caterer: pastry chef (unknown episodes) |
| Terrence Hartwell | .... | production assistant (unknown episodes) |
| Tricia Kangrga | .... | |
