The show's theme song "Low Rider" was performed by War.
Wife Angie Lopez is played by Constance Marie whose birth name is Constance Marie Lopez.
During an appearance on "The Sharon Osbourne Show" (2003)'George Lopez' revealed it was his wife who first suggested 'Constance Marie' for the role of George's TV wife Angie.
The character 'George Lopez' was ranked #18 in TV Guide's list of the "50 Greatest TV Dads of All Time" (20 June 2004 issue).
In every episode, a new inspirational saying is written on the chalkboard on the side of the Lopezes' refrigerator.
Scenes taking place in Carmen's room reveal that she is a fan of Linkin Park and 3 Doors Down.
In the earlier seasons of the show Belita Moreno who plays George's mother can be clearly seen wearing some heavy "age" makeup. This may be due to the fact that she is only ten years his senior. Later the makeup shows up less most likely after the audiences accepted Belito as his mother.