| Ellen Pompeo | ... | Dr. Meredith Grey (79 episodes, 2005-2008) |
| Sandra Oh | ... | Dr. Cristina Yang (79 episodes, 2005-2008) |
| Katherine Heigl | ... | Dr. Isobel 'Izzie' Stevens (79 episodes, 2005-2008) |
| Justin Chambers | ... | Dr. Alex Karev (79 episodes, 2005-2008) |
| T.R. Knight | ... | Dr. George O'Malley (79 episodes, 2005-2008) |
 | Chandra Wilson | ... | Dr. Miranda Bailey (79 episodes, 2005-2008) |
| James Pickens Jr. | ... | Dr. Richard Webber (79 episodes, 2005-2008) |
| Patrick Dempsey | ... | Dr. Derek Shepherd (79 episodes, 2005-2008) |
| Isaiah Washington | ... | Dr. Preston Burke (61 episodes, 2005-2007) |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd / ... (54 episodes, 2005-2008) |
| Sara Ramirez | ... | Dr. Callie Torres (51 episodes, 2006-2008) |
| Eric Dane | ... | Dr. Mark Sloan (43 episodes, 2006-2008) |
| Steven W. Bailey | ... | Joe / ... (28 episodes, 2005-2007) |
| Chyler Leigh | ... | Dr. Lexie Grey (20 episodes, 2007-2008) |
| Moe Irvin | ... | Nurse Tyler Christian / ... (20 episodes, 2005-2008) |
| Brooke Smith | ... | Dr. Erica Hahn (19 episodes, 2006-2008) |
| Elizabeth Reaser | ... | Jane Doe / ... (17 episodes, 2007-2008) |
| Sarah Utterback | ... | Nurse Olivia Harper (17 episodes, 2005-2007) |
| Kate Burton | ... | Ellis Grey (15 episodes, 2005-2007) |
| Jeffrey Dean Morgan | ... | Denny Duquette / ... (15 episodes, 2006-2008) |
| Linda Klein | ... | Nurse Linda / ... (13 episodes, 2005-2007) |
| Ray Ford | ... | Ray the Paramedic / ... (12 episodes, 2005-2007) |
| Robin Pearson Rose | ... | Patricia (11 episodes, 2005-2007) |
| Jeff Perry | ... | Thatcher Grey (10 episodes, 2006-2007) |
| Lauren Stamile | ... | Nurse Rose (10 episodes, 2007-2008) |
| Loretta Devine | ... | Adele Webber (10 episodes, 2005-2008) |
| Joseph Williamson | ... | Intern Pierce / ... (10 episodes, 2007-2008) |
| Kathleen M. Darcy | ... | Anesthesiologist / ... (10 episodes, 2005-2006) |
| Kate Anthony | ... | Nurse Kate / ... (10 episodes, 2006-2008) |
| Jeremy Rabb | ... | ER Resident / ... (10 episodes, 2005-2007) |
| Chris O'Donnell | ... | Dr. Finn Dandridge (9 episodes, 2006) |
| Mark Saul | ... | Intern Steve (9 episodes, 2007-2008) |
| Joy Osmanski | ... | Intern Lucy (9 episodes, 2007-2008) |
| Kali Rocha | ... | Dr. Sydney Heron (8 episodes, 2006-2007) |
| Candice Afia | ... | Intern Laura / ... (8 episodes, 2007-2008) |
| Molly Kidder | ... | Intern Megan (8 episodes, 2007-2008) |
| Tymberlee Chanel | ... | Intern Claire / ... (8 episodes, 2007-2008) |
| Cress Williams | ... | Tucker Jones (7 episodes, 2006-2008) |
| Amrapali Ambegaokar | ... | Intern Dani (7 episodes, 2007-2008) |
| George Dzundza | ... | Harold O'Malley (7 episodes, 2005-2007) |
| John O'Brien | ... | Lab Tech / ... (7 episodes, 2005-2008) |
| Mare Winningham | ... | Susan Grey (6 episodes, 2006-2007) |
| Amy Madigan | ... | Dr. Wyatt (6 episodes, 2008) |
| Patricia Bethune | ... | Nurse Ginger / ... (6 episodes, 2005-2007) |
| Cathy Lind Hayes | ... | Nurse Debbie / ... (6 episodes, 2005-2006) |
| Ariel Felix | ... | Anesthesiologist / ... (6 episodes, 2005-2008) |
| Noelle McCutchen | ... | Nurse Vivian / ... (6 episodes, 2005-2006) |
| Brooke Blanchard | ... | Jill the Paramedic (6 episodes, 2005-2007) |
| Anjul Nigam | ... | Dr. Raj Sen (6 episodes, 2005-2007) |
| Debra Monk | ... | Louise O'Malley (5 episodes, 2006-2008) |
| Greg Pitts | ... | Jerry O'Malley (5 episodes, 2005-2007) |
| Tim Griffin | ... | Ronny O'Malley (5 episodes, 2005-2007) |
| Linda Eve Miller | ... | E.R. Nurse / ... (5 episodes, 2005-2007) |
| Gloria Garayua | ... | Intern Graziella (5 episodes, 2007-2008) |
| Diahann Carroll | ... | Jane Burke (5 episodes, 2006-2007) |
| John Cappon | ... | John the Paramedic / ... (5 episodes, 2005-2007) |
| Winston Story | ... | Intern Leo (5 episodes, 2007-2008) |
| Tsai Chin | ... | Helen Rubenstein (4 episodes, 2005-2007) |
| Jack Yang | ... | Walter (4 episodes, 2005-2007) |
| Yvette Cruise | ... | Scrub Nurse / ... (4 episodes, 2005-2007) |
| Maile Flanagan | ... | Lab Tech / ... (4 episodes, 2005-2007) |
| Richard Keith | ... | Intern Mitch (4 episodes, 2007-2008) |
| Nicole Cummins | ... | Nicole the Paramedic / ... (4 episodes, 2007) |
| Kyle Chandler | ... | Dylan Young (4 episodes, 2006-2007) |
| Kerry Carney | ... | Intern #1 / ... (4 episodes, 2005-2006) |
| Edward Herrmann | ... | Dr. Norman Shales (3 episodes, 2007) |
| Roger Rees | ... | Dr. Colin Marlow (3 episodes, 2007) |
| Mandy Siegfried | ... | Molly Thompson (3 episodes, 2006-2007) |
| Jack Axelrod | ... | Really Old Guy / ... (3 episodes, 2006-2007) |
| Shenita Moore | ... | Surgical Nurse / ... (3 episodes, 2005-2007) |
| Terrance Christopher Jones | ... | Paramedic / ... (3 episodes, 2007-2008) |
| Crystal Kwon | ... | Nurse Jolene (3 episodes, 2007) |
| Joyce Guy | ... | Administrator / ... (3 episodes, 2005-2007) |
| Helene McCardle | ... | ER Doc / ... (3 episodes, 2005-2006) |
| Wayne Lopez | ... | Paramedic #2 / ... (3 episodes, 2006) |
| Rob Narita | ... | Anesthesiologist / ... (3 episodes, 2006-2007) |
| Martin Yu | ... | Anesthesiologist / ... (3 episodes, 2006-2007) |
| Zibby Allen | ... | Cute Nurse / ... (3 episodes, 2006-2007) |
| Chad Fish | ... | Anesthesiologist / ... (3 episodes, 2005-2006) |
| Christina Ricci | ... | Hannah Davies (2 episodes, 2006) |
| Margaret Welsh | ... | Dorie Russell (2 episodes, 2005) |
| Anna Maria Horsford | ... | Liz Fallon (2 episodes, 2005-2007) |
| Curtis Armstrong | ... | Robert Martin (2 episodes, 2005) |
| Paul Adelstein | ... | Dr. Cooper Freedman (2 episodes, 2007) |
| Pat Healy | ... | Tom Russell (2 episodes, 2005) |
| Jillian Armenante | ... | Mindy Carlson (2 episodes, 2006) |
| Monica Keena | ... | Bonnie Crasnoff (2 episodes, 2005-2007) |
| Amy Brenneman | ... | Dr. Violet Turner (2 episodes, 2007) |
| Gale Harold | ... | Shane (2 episodes, 2007) |
| Tim Daly | ... | Dr. Pete Wilder (2 episodes, 2007) |
| Dean Norris | ... | Vince (2 episodes, 2007) |
| Tessa Thompson | ... | Camille Travis (2 episodes, 2006) |
| Clea DuVall | ... | Jennifer Robinson (2 episodes, 2008) |
| Taye Diggs | ... | Dr. Sam Bennett (2 episodes, 2007) |
| Kelly Wolf | ... | Carly Height (2 episodes, 2007) |
| Hallee Hirsh | ... | Claire (2 episodes, 2006) |
| John Billingsley | ... | Jacob Nolston (2 episodes, 2007) |
| Aasha Davis | ... | Rina (2 episodes, 2007) |
| Merrin Dungey | ... | Dr. Naomi Bennett (2 episodes, 2007) |
| Paul Perri | ... | Rick's Friend (2 episodes, 2007) |
| Tiffany Hines | ... | Natalie (2 episodes, 2006) |
| Jack Merrill | ... | Lab Tech / ... (2 episodes, 2005) |
| Chris Lowell | ... | William 'Dell' Parker (2 episodes, 2007) |
| Kevin Rankin | ... | Jack Vaughan (2 episodes, 2007) |
| Mae Whitman | ... | Heather Douglas (2 episodes, 2007) |
| Jeffrey Markle | ... | Greg (2 episodes, 2007) |
| Judith Hoag | ... | Rhada Douglas (2 episodes, 2007) |
| Kimberly Huie | ... | Mary Daltrey (2 episodes, 2007) |
| Alison La Placa | ... | Mrs. Nolston (2 episodes, 2007) |
| Theo Rossi | ... | Stan Giamatti (2 episodes, 2007) |
| Brian Tee | ... | Andy (2 episodes, 2007) |
| Jason O'Mara | ... | Phillip Robinson (2 episodes, 2008) |
| John Bishop | ... | James Carlson (2 episodes, 2006) |
| Charles Duckworth | ... | Brian (2 episodes, 2006) |
| Billy Mayo | ... | Rick (2 episodes, 2007) |
| Elaine Kao | ... | NICU Nurse (2 episodes, 2005-2007) |
| Brian Chenoweth | ... | Scared Guy / ... (2 episodes, 2007) |
| Paula Weston Solano | ... | OB Nurse (2 episodes, 2006) |
| Seth Green | ... | Nick Hanscom (2 episodes, 2007) |
| D.W. Moffett | ... | Alan / ... (2 episodes, 2007) |
| Derek Phillips | ... | Dale (2 episodes, 2007) |
| Danielle Kennedy | ... | Angry Woman (2 episodes, 2007) |
| Bellamy Young | ... | Kathy (2 episodes, 2007) |
| Marty Lodge | ... | Anaesthsiologist / ... (2 episodes, 2005-2006) |
| Paul Norwood | ... | Scared Guy #2 (2 episodes, 2007) |
| Raphael Sbarge | ... | Paul (2 episodes, 2007) |
| Shanelle Workman | ... | Sara Giamatti (2 episodes, 2007) |
| Madison Leisle | ... | Lisa The Child / ... (2 episodes, 2007) |
| Stephanie Niznik | ... | Carol (2 episodes, 2007) |
| Keeshan Giles | ... | Intern #2 / ... (2 episodes, 2005-2006) |
| Maria Elena Maglaris | ... | Nurse Maria (2 episodes, 2006-2008) |
| David Anders | ... | Jim (2 episodes, 2007) |
| Yvans Jourdain | ... | Businessman (2 episodes, 2007) |
| Tim Chiou | ... | Paramedic / ... (2 episodes, 2007) |
| Becky Wahlstrom | ... | Lisa (2 episodes, 2007) |
| Cameron Watson | ... | Rick (2 episodes, 2007) |
| Mac Brandt | ... | Paramedic #3 (2 episodes, 2007) |
| Roger Bridges | ... | Firefighter (2 episodes, 2007) |
| Gary Hershberger | ... | Doug (2 episodes, 2007) |
| Parisa Fitz-Henley | ... | Cammy (2 episodes, 2007) |
| Nick Hoffa | ... | Firefighter #2 (2 episodes, 2007) |
| Shavon Kirksey | ... | Maya Bennett (2 episodes, 2007) |
| Emma Prescott | ... | Lucy / ... (2 episodes, 2007) |
| Suzi Hofrichter | ... | Sandra Nolston (2 episodes, 2007) |
| Parker Goris | ... | Garrett Nolston (2 episodes, 2007) |
| Mary Joy | ... | Tillie (2 episodes, 2007) |
| Garon Grigsby | ... | Keith (2 episodes, 2007) |
| Jane Clark | ... | Nurse (2 episodes, 2007) |
| Trista Delamere | ... | S.G.H. Clinic Nurse (2 episodes, 2007) |
| William Jackson | ... | Old Man (2 episodes, 2007) |
| Robin Hines | ... | Cute Girl (2 episodes, 2007) |
| Sean Palmer | ... | Intern / ... (2 episodes, 2005) |
| Kristy Munden | ... | Nurse #2 / ... (2 episodes, 2005) |
| Andre Panossian | ... | Code Team Leader / ... (2 episodes, 2005) |
| Walter Wong | ... | Echo Tech / ... (2 episodes, 2005) |
| Keith Sellon-Wright | ... | Surgeon #1 (2 episodes, 2006) |
| David Paluck | ... | Surgeon #2 (2 episodes, 2006) |
| Billy Wood | ... | Perfectionist / ... (2 episodes, 2005-2007) |
| Rigo Sanchez | ... | Paramedic / ... (2 episodes, 2005-2006) |
| Harris Michaels | ... | Orderly (2 episodes, 2006-2007) |
| Kate Mines | ... | Burke's Nurse / ... (2 episodes, 2006-2007) |
| Meggan Anderson | ... | Nurse (2 episodes, 2007-2008) |
| Janina Gavankar | ... | Lisa (2 episodes) |
|
| Betsy Beers | .... | executive producer (78 episodes, 2005-2008) |
| Tammy Ann Casper | .... | producer / co-producer (78 episodes, 2005-2008) |
| Rob Corn | .... | producer / executive producer (78 episodes, 2005-2008) |
| Mark Gordon | .... | executive producer (78 episodes, 2005-2008) |
| Shonda Rhimes | .... | executive producer (78 episodes, 2005-2008) |
| Krista Vernoff | .... | executive producer / co-executive producer / ... (75 episodes, 2005-2008) |
| Mark Wilding | .... | co-executive producer / executive producer (69 episodes, 2005-2008) |
| Tony Phelan | .... | co-executive producer / producer / ... (65 episodes, 2005-2008) |
| Joan Rater | .... | supervising producer / producer / ... (65 episodes, 2005-2008) |
| Lisa Taylor | .... | associate producer / co-producer (55 episodes, 2005-2008) |
| Peter Horton | .... | executive producer / co-executive producer (55 episodes, 2005-2007) |
| Kip Koenig | .... | supervising producer / consulting producer (55 episodes, 2005-2007) |
| Gabrielle G. Stanton | .... | supervising producer / producer (47 episodes, 2005-2007) |
| Harry Werksman | .... | supervising producer / producer (47 episodes, 2005-2007) |
| Debora Cahn | .... | supervising producer / consulting producer (42 episodes, 2006-2008) |
| Allan Heinberg | .... | co-executive producer / consulting producer / ... (42 episodes, 2006-2008) |
| Linda Klein | .... | producer (42 episodes, 2006-2008) |
| Zoanne Clack | .... | co-producer / producer (37 episodes, 2006-2008) |
| James D. Parriott | .... | executive producer (36 episodes, 2005-2006) |
| Mimi Schmir | .... | supervising producer / producer (30 episodes, 2005-2006) |
| Karin Gleason | .... | associate producer (17 episodes, 2007-2008) |
| Stacy McKee | .... | producer (17 episodes, 2007-2008) |
| Jeff Rafner | .... | producer (17 episodes, 2007-2008) |
| Chris Van Dusen | .... | associate producer (17 episodes, 2007-2008) |
| Marti Noxon | .... | consulting producer / executive producer (14 episodes, 2007) |
| Jill Soloway | .... | consulting producer (8 episodes, 2007) |
| Ben Neumann | .... | consulting producer (7 episodes, 2005-2007) |
| Ann Lewis Hamilton | .... | consulting producer (7 episodes, 2005) |
| Ann Kindberg | .... | co-producer (5 episodes, 2005) |
| Jenna Bans | .... | producer / supervising producer (5 episodes, 2008) |
| Nancy Bordson | .... | executive producer (4 episodes, 2006-2007) |
| Mark Foreman | .... | producer (4 episodes, 2006-2007) |
| Kent Hodder | .... | executive producer (4 episodes, 2006-2007) |
| Steve Mulholland | .... | executive producer (4 episodes, 2006-2007) |
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